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Test ID: CHIST Histoplasma Antibody, Spinal Fluid

Reporting Name

Histoplasma Ab, CSF

Useful For

Aiding in the diagnosis of Histoplasma meningitis in spinal fluid specimens

Clinical Information

Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched with bird droppings. The usual disease is self-limited, affects the lungs, and is asymptomatic. Chronic cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially in young children and immunosuppressed patients.

Interpretation

Any positive serologic result in spinal fluid is significant.

 

Simultaneous appearance of the H and M precipitin bands indicates active histoplasmosis.

 

The M band alone indicates active or chronic disease or a recent skin test for histoplasmosis.

Analytic Time

2 days

Day(s) and Time(s) Performed

Monday; 6 a.m.

Tuesday through Friday; 9:30 a.m.

Clinical Reference

1. Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In: Manual of Clinical and Laboratory Immunology. ASM Press.1997

2. Deepe GS: Histoplasma capsulatum Histoplasmosis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:3162-3176

Method Name

Complement Fixation (CF)/Immunodiffusion

Specimen Type

CSF


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

MYCELIAL BY COMPLEMENT FIXATION (CF)

Negative (positives reported as titer)

 

YEAST BY CF

Negative (positives reported as titer)

 

ANTIBODY BY IMMUNODIFFUSION

Negative (positives reported as band present)

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86698 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CHIST Histoplasma Ab, CSF 91684-1

 

Result ID Test Result Name Result LOINC Value
15118 Histoplasma Mycelial (CSF) 27220-3
15119 Histoplasma Yeast (CSF) 27209-6
15120 Histoplasma Immunodiffusion (CSF) 91682-5

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.

Mayo Clinic Laboratories | Neurology Catalog Additional Information:

mml-CNS-Infections, mml-Pediatric