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Test ID: MSP2 Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid

Reporting Name

Multiple Sclerosis Profile

Useful For

Diagnosing multiple sclerosis, especially helpful in patients with equivocal clinical or radiological findings

Clinical Information

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease characterized by visual, motor, and sensory disturbances. The diagnosis of MS is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include the cerebrospinal fluid (CSF) IgG index and CSF oligoclonal band detection.


Oligoclonal banding (OCB): ≥4 cerebrospinal fluid (CSF)-specific bands are consistent with multiple sclerosis (MS).


CSF IgG index: >0.85 is consistent with MS.


Abnormal CSF IgG indexes and OCB patterns have been reported in 70% to 80% of MS patients. If both tests are performed, at least 1 of the tests has been reported to be positive in more than 90% of multiple sclerosis patients. A newer methodology for OCB detection, isoelectric focusing, is utilized in this test and has been reported to be more sensitive (90%-95%).


The presence of OCB or elevated CSF IgG index is unrelated to disease activity.

Profile Information

Test ID Reporting Name Available Separately Always Performed
OLIGC CSF Bands No, (Order OLIG, submit CSF and Serum) Yes
OLIGS Serum Bands No, (Order OLIG, submit CSF and Serum) Yes
SFINC IgG Index, CSF No, (Order SFIN, submit CSF and Serum or CASF for CSF only) Yes
SFINS IgG, S No, (Order SFIN, submit CSF and Serum) Yes

Analytic Time

2 days

Day(s) and Time(s) Performed

Monday through Saturday; 7 a.m.-12 p.m.

Clinical Reference

1. Andersson M, Alvarez-Cermeno J, Bernardi G, et al: Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J Neurol Neurosurg Psychiatry 1994 Aug;57(8):897-902

2. Tourtellotte WW, Walsh MJ, Baumhefner RW, et al: The current status of multiple sclerosis intra-blood-brain-barrier IgG synthesis. Ann NY Acad Sci 1984;436:52-67

Method Name

OLIGC, OLIGS: Isoelectric Focusing (IEF) with IgG Immunoblot Detection

SFINC, SFINS: Nephelometry

Specimen Type


Specimen Required

Both serum and spinal fluid are required. Spinal fluid must be obtained within 1 week of serum draw.


Specimen Type: Serum


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL

Collection Instructions: Label specimen as serum.


Specimen Type: Spinal fluid

Container/Tube: Sterile vial

Specimen Volume: 1 mL

Collection Instructions: Label specimen as spinal fluid.

Specimen Minimum Volume

Serum, Spinal Fluid: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reference Values


<4 bands



CSF IgG index: 0.00-0.85

CSF IgG: 0.0-8.1 mg/dL

CSF albumin: 0.0-27.0 mg/dL

Serum IgG

0-4 months: 100-334 mg/dL

5-8 months: 164-588 mg/dL

9-14 months: 246-904 mg/dL

15-23 months: 313-1,170 mg/dL

2-3 years: 295-1,156 mg/dL

4-6 years: 386-1,470 mg/dL

7-9 years: 462-1,682 mg/dL

10-12 years: 503-1,719 mg/dL

13-15 years: 509-1,580 mg/dL

16-17 years: 487-1,327 mg/dL

≥18 years: 767-1,590 mg/dL

Serum albumin: 3,200-4,800 mg/dL

CSF IgG/albumin: 0.0-0.21

Serum IgG/albumin: 0.00-0.40

CSF IgG synthesis rate: 0-12 mg/24 hours

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information



82784 x 2

83916 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MSP2 Multiple Sclerosis Profile 55121-8


Result ID Test Result Name Result LOINC Value
2783 Serum Bands 56974-9
INDEX IgG Index, CSF 14117-6
8017 CSF Bands 56764-4
IGG_S IgG, S 2465-3
ALB_S Albumin, S 1751-7
23611 CSF Olig Bands Interpretation 49852-7
IGG_C IgG, CSF 2464-6
ALB_C Albumin, CSF 1746-7
AIGAS IgG/Albumin, S 6782-7
AIGAC IgG/Albumin, CSF 2470-3
SRATE Synthesis Rate, CSF 14116-8


If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.

Mayo Clinic Laboratories | Neurology Catalog Additional Information:

mml-Behavioral, mml-Epilepsy, mml-Movement-Disorders, mml-Demyelinating-Diseases, mml-Neuroimmunology, mml-Pediatric, mml-Pain