Test ID: SCL70 Scl 70 Antibodies, IgG, Serum
Reporting Name
Scl 70 Ab, IgG, SUseful For
Evaluating patients with signs and symptoms of scleroderma and other connective tissue diseases in whom the test for antinuclear antibodies is positive
Testing for Scl 70 antibodies are not useful in patients without demonstrable antinuclear antibodies.
Clinical Information
Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70 antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of patients with this connective tissue disease. Scl 70 antibodies are more common in patients with extensive cutaneous involvement and interstitial pulmonary fibrosis, and are considered a poor prognostic sign.(1,2)
See Connective Tissue Disease Cascade (CTDC) in Special Instructions.
Interpretation
A positive test result for Scl 70 antibodies is consistent with a diagnosis of scleroderma.
Testing Algorithm
See Connective Tissue Disease Cascade (CTDC) in Special Instructions.
Report Available
1 to 3 daysDay(s) Performed
Monday through Saturday
Clinical Reference
1. Homburger H, Larsen S: Detection of specific antibodies. In Clinical Immunology: Principles and Practice. First edition. Edited by R Rich, T Fleisher, B Schwartz, et al. St. Louis, Mosby-Year Book, Inc, 1996, pp 2096-2109
2. White B: Systemic sclerosis. In Clinical Immunology Principles and Practice. Second edition. Edited by R Rich, T Fleisher, W Shearer, et al. St. Louis, Mosby-Year Book, 2001, pp 64.1-64.10
Method Name
Multiplex Flow Immunoassay
Specimen Type
SerumSpecimen Required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 21 days | |
Frozen | 21 days |
Special Instructions
Reference Values
<1.0 U (negative)
≥1.0 U (positive)
Reference values apply to all ages.
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86235
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
SCL70 | Scl 70 Ab, IgG, S | 47322-3 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
SCL70 | Scl 70 Ab, IgG, S | 47322-3 |
mml-Behavioral, mml-Demyelinating-Diseases, mml-Neuroimmunology, mml-Pediatric, mml-Spinal-Cord