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Test ID: SHSTO Histoplasma Antibody, Serum

Reporting Name

Histoplasma Ab, S

Useful For

Aiding in the diagnosis of active histoplasmosis in serum specimens

Clinical Information

Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched with bird droppings. The usual disease is self-limited, affects the lungs, and is asymptomatic. Chronic cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially in young children and in immunosuppressed patients.

Interpretation

Complement fixation (CF) titers of 1:32 or higher indicate active disease. A rising CF titer is associated with progressive infection.

 

Positive immunodiffusion test results supplement findings of the CF test. The simultaneous appearance of both H and M precipitin bands indicates active histoplasmosis. The M precipitin band alone indicates early or chronic disease or a recent histoplasmosis skin test.

 

Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.

Testing Algorithm

See Meningitis/Encephalitis Panel Algorithm in Special Instructions.

Analytic Time

2 days

Day(s) and Time(s) Performed

Monday; 6 a.m.

Tuesday through Friday; 9:30 a.m.

Clinical Reference

Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of Clinical and Laboratory Immunology. Fifth edition. Washington DC, ASP Press, 1997

Method Name

Complement Fixation (CF)/Immunodiffusion

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

See Specimen Required.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

MYCELIAL BY COMPLEMENT FIXATION (CF)

Negative (positives reported as titer)

 

YEAST BY CF

Negative (positives reported as titer)

 

ANTIBODY BY IMMUNODIFFUSION

Negative (positives reported as band present)

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86698 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SHSTO Histoplasma Ab, S 90227-0

 

Result ID Test Result Name Result LOINC Value
15121 Histoplasma Mycelial 20573-2
15122 Histoplasma Yeast 20574-0
15123 Histoplasma Immunodiffusion 90232-0

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.

Mayo Clinic Laboratories | Neurology Catalog Additional Information:

mml-CNS-Infections, mml-Pediatric