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Test ID: SPSM Morphology Evaluation (Special Smear), Blood

Reporting Name

Morphology Eval (special smear)

Useful For

Detecting disease states or syndromes of the white blood cells, red blood cells, or platelet cell lines of a patient's peripheral blood

Clinical Information

Under normal conditions, the morphology and proportion of each blood cell type is fairly consistent in corresponding age groups. The morphology and proportion of each blood cell type may change in various hematologic diseases. Differential leukocyte count and special smear evaluation is helpful in revealing the changes in morphology or proportion of each cell type in the peripheral blood.


The laboratory will provide an interpretive report of percentage of white cells and, if appropriate, evaluation of white cells, red cells, and platelets.

Profile Information

Test ID Reporting Name Available Separately Always Performed
DIFFS Morphology Eval (Special Smear) No Yes
SPSM_ Special Smear No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
PINTP Peripheral Smear Interpretation No No
CBCN CBC without Differential Yes No

Testing Algorithm

If clinically abnormal results are identified by microscopic examination, a peripheral blood smear review is performed by a Hematopathologist at an additional charge.


If patient has not had a complete blood cell count in the last 3 days, one will be performed at an additional charge.


See Acute Tick-Borne Disease Testing Algorithm

Report Available

1 day

Day(s) Performed

Sunday through Saturday

Clinical Reference

1. Kjeldsberg CR, eds. Practical Diagnosis of Hematologic Disorders. 5th ed. American Society of Clinical Pathologists; 2010

2. Pozdnyakova O, Connell NT, Battinelli EM, Connors JM, Fell G, Kim AS. Clinical significance of CBC and WBC morphology in the diagnosis and clinical course of COVID-19 infection. Am J Clin Pathol.. 2021 Feb 11;155(3):364-375. doi: 10.1093/ajcp/aqaa231

Method Name

Manual-Microscopic Examination of Cells


Specimen Type

Whole blood

Necessary Information

Clinician should provide indication for performing test.

Specimen Required

Collection Container/Tube: 2 slides

Specimen Volume: 2 unstained, well prepared peripheral blood smears

Collection Instructions: Smears made from blood obtained by either a lavender top (EDTA) tube or finger stick specimen

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Ambient (preferred) CARTRIDGE
  Refrigerated  CARTRIDGE

Reference Values

1-3 years

Neutrophils/bands: 22-51%

Lymphocytes: 37-73%

Monocytes: 2-11%

Eosinophils: 1-4%

Basophils: 0-2%

Metamyelocytes: 0%

Myelocytes: 0%


4-7 years

Neutrophils/bands: 30-65%

Lymphocytes: 29-65%

Monocytes: 2-11%

Eosinophils: 1-4%

Basophils: 0-2%

Metamyelocytes: 0%

Myelocytes: 0%


8-13 years

Neutrophils/bands: 35-70%

Lymphocytes: 23-53%

Monocytes: 2-11%

Eosinophils: 1-4%

Basophils: 0-2%

Metamyelocytes: 0%

Myelocytes: 0%



Neutrophils/bands: 50-75%

Lymphocytes: 18-42%

Monocytes: 2-11%

Eosinophils: 1-3%

Basophils: 0-2%

Metamyelocytes: <1%

Myelocytes: <0.5%


An interpretive report will be provided.

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


85060-(if appropriate)

85027-(if appropriate)

88184-(If appropriate)

88185-(If appropriate)

88187-(if appropriate)

88188-(if appropriate)

88189-(if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SPSM Morphology Eval (special smear) 14869-2


Result ID Test Result Name Result LOINC Value
SEGBA Neutrophilic Segs and Bands 23761-0
LYMPH Lymphocytes 26478-8
MONOC Monocytes 26485-3
EOS Eosinophils 714-6
BASO Basophils 707-0
META Metamyelocytes 740-1
MYEL Myelocytes 749-2
PROMY Promyelocytes 783-1
UBLS Blasts 709-6
PLSM Plasma Cells 79426-3
M_KR Megakaryocytes 19252-6
NUCL Nucleated RBC 19048-8
FRAGC Fragile Cells 34992-8
BL_PR Blasts and Promonocytes 709-6
MANC Manual Absolute Neutrophil Count 753-4
INT01 Interpretation 59466-3
REV96 Reviewed by: 18771-6
Mayo Clinic Laboratories | Neurology Catalog Additional Information:

mml-Behavioral, mml-Movement-Disorders, mml-Pediatric